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Article

Pleiotropic effect of the ABCG2 gene in gout: involvement in serum urate levels and progression from hyperuricemia to gout.

Arthritis research & therapy - 12 Mar 2020

Wrigley Rebekah, Phipps-Green Amanda J, Topless Ruth K, Major Tanya J, Cadzow Murray, Riches Philip, Tausche Anne-Kathrin, Janssen Matthijs, Joosten Leo A B, Jansen Tim L, So Alexander, Harré Hindmarsh Jennie, Stamp Lisa K, Dalbeth Nicola, Merriman Tony R

Abstract excerpt

BACKGROUND: The ABCG2 Q141K (rs2231142) and rs10011796 variants associate with hyperuricaemia (HU). The effect size of ABCG2 rs2231142 on urate is ~ 60% that of SLC2A9, yet the effect size on gout is greater. We tested the hypothesis that ABCG2 plays a role in the progression from HU to gout by testing for association of ABCG2 rs2231142 and rs10011796 with gout using HU controls. METHODS: We analysed 1699...

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
Share to Epistasis, Genetic
Share to Europe
Share to Genetic Pleiotropy
Share to Gout
Share to Hyperuricemia
Share to New Zealand
Share to Uric Acid

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Identifiers

PMID: 32164793
DOI: 10.1186/s13075-020-2136-z
PMCID: PMC7069001

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