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Article

ABCG2 polymorphisms in gout: insights into disease susceptibility and treatment approaches

1 Apr 2017

Abstract excerpt

, Q141K) in the ATP-binding cassette G2 (ABCG2) transporter with serum urate concentration in a genome-wide association study, it was revealed that ABCG2 is an important uric acid transporter. This review discusses the relevance of ABCG2 polymorphisms in gout, possible etiological mechanisms, and treatment approaches. The 141K ABCG2 urate-increasing variant causes instability in the nucleotide-binding domain,...

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PMID: 28461764
DOI: 10.2147/pgpm.s105854

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