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Article

Medically Important Alterations in Transport Function and Trafficking of ABCG2.

International journal of molecular sciences - 10 Mar 2021

Homolya László

Abstract excerpt

Several polymorphisms and mutations in the human ABCG2 multidrug transporter result in reduced plasma membrane expression and/or diminished transport function. Since ABCG2 plays a pivotal role in uric acid clearance, its malfunction may lead to hyperuricemia and gout. On the other hand, ABCG2 residing in various barrier tissues is involved in the innate defense mechanisms of the body; thus, genetic alterations in...

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Models, Genetic

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 33801813
DOI: 10.3390/ijms22062786
PMCID: PMC8001156

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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