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Structure of the Helicobacter pylori CagA oncoprotein bound to the human tumor suppressor ASPP2

13 Jan 2014

Abstract excerpt

The Cytotoxin associated gene A (CagA) protein of Helicobacter pylori is associated with increased virulence and risk of cancer. Recent proteomic studies have demonstrated an association of CagA with the human tumor suppressor Apoptosis-stimulating Protein of p53-2 (ASPP2). We present here a genetic, biochemical, and structural analysis of CagA with ASPP2. Domain delineation of the 120-kDa CagA protein revealed a...

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PMID: 24474782
DOI: 10.1073/pnas.1320631111

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