Article
Crystal structure of the Helicobacter pylori vacuolating toxin p55 domain.
Proceedings of the National Academy of Sciences of the United States of America - 9 Oct 2007
Gangwer Kelly A, Mushrush Darren J, Stauff Devin L, Spiller Ben, McClain Mark S, Cover Timothy L, Lacy D Borden
Abstract excerpt
Helicobacter pylori VacA, a pore-forming toxin secreted by an autotransporter pathway, causes multiple alterations in human cells, contributes to the pathogenesis of peptic ulcer disease and gastric cancer, and is a candidate antigen for inclusion in an H. pylori vaccine. Here, we present a 2.4-A crystal structure of the VacA p55 domain, which has an important role in mediating VacA binding to host cells. The...
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