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Article

Structural insights into <i>Helicobacter pylori</i> oncoprotein CagA interaction with β1 integrin

20 Aug 2012

Abstract excerpt

Infection with the gastric pathogen Helicobacter pylori is a risk factor for the development of gastric cancer. Pathogenic strains of H. pylori carry a type IV secretion system (T4SS) responsible for the injection of the oncoprotein CagA into host cells. H. pylori and its cag-T4SS exploit α5β1 integrin as a receptor for CagA translocation. Injected CagA localizes to the inner leaflet of the host cell membrane,...

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PMID: 22908298
DOI: 10.1073/pnas.1206098109

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