Article
Structural analysis of the virulence gene protein IceA2 from Helicobacter pylori.
Biochemical and biophysical research communications - 5 Jul 2022
Cho Hye Yeon, Cho Hongbaek, Song Wan Seok, Yoon Sung-Il
Abstract excerpt
Helicobacter pylori is a pathogenic bacterium that causes gastric ulcers and cancer. Among the diverse virulence genes of H. pylori, the IceA gene was identified to be expressed upon adherence to host cells. The IceA gene has two alleles, iceA1 and iceA2, which encode completely different proteins. IceA1 protein was shown to exert endonuclease activity, whereas IceA2 has never been analyzed at the molecular...
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