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Natural variant of the <i>Helicobacter pylori</i> CagA oncoprotein that lost the ability to interact with <scp>PAR</scp>1

19 Dec 2013

Abstract excerpt

Helicobacter pylori strains carrying the cagA gene are associated with severe disease outcomes, most notably gastric cancer. CagA protein is delivered into gastric epithelial cells by a type IV secretion system. The translocated CagA undergoes tyrosine phosphorylation at the C-terminal EPIYA motifs by host cell kinases. Tyrosine-phosphorylated CagA acquires the ability to interact with and activate SHP2, thereby...

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PMID: 24354359
DOI: 10.1111/cas.12342

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