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Article

CagA–ASPP2 complex mediates loss of cell polarity and favors H. pylori colonization of human gastric organoids

21 Jan 2020

Abstract excerpt

Significance Infection by the bacterium Helicobacter pylori is the main risk factor for stomach cancer. Strains of H. pylori that produce the virulence factor CagA substantially increase stomach cancer risk compared with strains without CagA. CagA disrupts cell polarity—the specialized asymmetric organization within cells—but the mechanism it uses and its influence on colonization are not fully understood. Using...

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PMID: 31964836
DOI: 10.1073/pnas.1908787117

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