Article
Helicobacter pylori cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host.
Proceedings of the National Academy of Sciences of the United States of America - 31 May 2011
Buti Ludovico, Spooner Eric, Van der Veen Annemarthe G, Rappuoli Rino, Covacci Antonello, Ploegh Hidde L
Abstract excerpt
Type I strains of Helicobacter pylori (Hp) possess a pathogenicity island, cag, that encodes the effector protein cytotoxin-associated gene A (CagA) and a type four secretion system. After translocation into the host cell, CagA affects cell shape, increases cell motility, abrogates junctional activity, and promotes an epithelial to mesenchymal transition-like phenotype. Transgenic expression of CagA enhances...
Topics
- Amino Acid Sequence
- Antigens, Bacterial
- Apoptosis
- Apoptosis Regulatory Proteins
- Bacterial Proteins
- DNA
- Doxorubicin
- Gene Expression Regulation
- Genes, Tumor Suppressor
- Helicobacter pylori
- Humans
- Molecular Sequence Data