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Article

Bacterial CagA protein induces degradation of p53 protein in a p14ARF-dependent manner

30 Jul 2014

Abstract excerpt

OBJECTIVE: Infection with Helicobacter pylori is the strongest known risk factor for adenocarcinoma of the stomach. Tumorigenic transformation of gastric epithelium induced by H. pylori is a highly complex process driven by an active interplay between bacterial virulence and host factors, many aspects of which remain obscure. In this work, we investigated the degradation of p53 tumour suppressor induced by H....

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Identifiers

PMID: 25080447
DOI: 10.1136/gutjnl-2014-307295

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