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Article

Catechol-O-methyltransferase activity does not influence emotional processing in men.

Journal of psychopharmacology (Oxford, England) - 1 Jun 2022

Martens Marieke Ag, Dalton Nina, Scaife Jessica, Harmer Catherine J, Harrison Paul J, Tunbridge Elizabeth M

Abstract excerpt

BACKGROUND: Catechol-O-methyltransferase (COMT) regulates cortical dopaminergic transmission and prefrontal-dependent cognitive function. However, its role in other cognitive processes, including emotional processing, is relatively unexplored. We therefore investigated the separate and interactive influences of COMT inhibition and Val158Met (rs4680) genotype on performance on an emotional test battery. METHODS:...

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Identifiers

PMID: 35443830
DOI: 10.1177/02698811221089032
PMCID: PMC9150146

Genes

COMT

Variants

rs4680

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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