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Article

Alpha 2B adrenoceptor genotype moderates effect of reboxetine on negative emotional memory bias in healthy volunteers.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 23 Oct 2013

Gibbs Ayana A, Bautista Carla E, Mowlem Florence D, Naudts Kris H, Duka Theodora

Abstract excerpt

Evidence suggests that emotional memory plays a role in the pathophysiology of depression/anxiety disorders. Noradrenaline crucially modulates emotional memory. Genetic variants involved in noradrenergic signaling contribute to individual differences in emotional memory and vulnerability to psychopathology. A functional deletion polymorphism in the α-2B adrenoceptor gene (ADRA2B) has been linked to emotional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24155306
DOI: 10.1523/JNEUROSCI.2124-13.2013
PMCID: PMC6618435

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