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Sex-dichotomous effects of functional COMT genetic variations on cognitive functions disappear after menopause in both health and schizophrenia.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Dec 2015

Papaleo Francesco, Sannino Sara, Piras Fabrizio, Spalletta Gianfranco

Abstract excerpt

Different genetic variations in the catechol-O-methyltransferase (COMT) gene have been indicated to functionally regulate the encoded enzyme. Despite the vast literature on the single nucleotide COMT ValMet polymorphism, the impact of complex haplotypes on cognitive functions has been overlooked. Here we contrasted the effects of complex COMT haplotypes with the ValMet polymorphism on cognitive functions and...

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Catechol O-Methyltransferase
Cognition Disorders
Menopause
Mental Status Schedule
Neuropsychological Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Schizophrenic Psychology

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PMID: 26560201
DOI: 10.1016/j.euroneuro.2015.10.005

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COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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