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Article

Influence of COMT val158met genotype on the depressed brain during emotional processing and working memory.

PloS one - 1 Jan 2013

Opmeer Esther M, Kortekaas Rudie, van Tol Marie-José, van der Wee Nic J A, Woudstra Saskia, van Buchem Mark A, Penninx Brenda W, Veltman Dick J, Aleman André

Abstract excerpt

Major depressive disorder (MDD) has been associated with abnormal prefrontal-limbic interactions and altered catecholaminergic neurotransmission. The val158met polymorphism on the catechol-O-methyltransferase (COMT) gene has been shown to influence prefrontal cortex (PFC) activation during both emotional processing and working memory (WM). Although COMT-genotype is not directly associated with MDD, it may affect...

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Source

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Identifiers

PMID: 24069183
DOI: 10.1371/journal.pone.0073290
PMCID: PMC3772077

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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