A signal peptide missense mutation associated with nicotine dependence alters α2*-nicotinic acetylcholine receptor function.

doi:10.1016/j.neuropharm.2014.01.021

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Article

A signal peptide missense mutation associated with nicotine dependence alters α2*-nicotinic acetylcholine receptor function.

Neuropharmacology - 1 Apr 2014

Dash Bhagirathi, Lukas Ronald J, Li Ming D

Abstract excerpt

A cytosine to thymidine (C → T) missense mutation in the signal peptide (SP) sequence (rs2472553) of the nicotinic acetylcholine receptor (nAChR) α2 subunit produces a threonine-to-isoleucine substitution (T22I) often associated with nicotine dependence (ND). We assessed effects on function of α2*-nAChR ('*'indicates presence of additional subunits) of this mutation, which could alter SP cleavage, RNA/protein...

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Identifiers

PMID: 24467848
DOI: 10.1016/j.neuropharm.2014.01.021
PMCID: PMC3984001

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