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RIF1: A novel regulatory factor for DNA replication and DNA damage response signaling

22 Jan 2014

Abstract excerpt

DNA double strand breaks (DSBs) are highly toxic to the cells and accumulation of DSBs results in several detrimental effects in various cellular processes which can lead to neurological, immunological and developmental disorders. Failure of the repair of DSBs spurs mutagenesis and is a driver of tumorigenesis, thus underscoring the importance of the accurate repair of DSBs. Two major canonical DSB repair...

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PMID: 24462468
DOI: 10.1016/j.dnarep.2013.12.004

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