Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular functions of BRCA1 in the DNA damage response.

Cancer biology & therapy - 1 Jun 2004

Scully Ralph, Xie Anyong, Nagaraju Ganesh

Abstract excerpt

Ten years ago, a concerted effort from several labs resulted in the cloning of BRCA1, the first of two major hereditary breast/ovarian cancer predisposition genes. Since that time, BRCA1 has been linked to several key nuclear functions connected with the prevention of genomic instability. In particular, BRCA1 functions in concert with Rad51, BRCA2 and other genes to control double strand break repair (DSBR) and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to DNA-Binding Proteins
Share to DNA Damage

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Repair

Share to Genes, BRCA1

Share to Genomic Instability

Share to Rad51 Recombinase

Share to Recombination, Genetic

Source

Identifiers

PMID: 15280660
DOI: 10.4161/cbt.3.6.842

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular functions of BRCA1 in the DNA damage response.PMID 15280660Read ↗

The role of BRCA1 in DNA damage response.Semantic proximity Read ↗

Emerging roles of BRCA1 in transcriptional regulation and DNA repair.Semantic proximity Read ↗

BRCA1: Beyond double-strand break repair.Semantic proximity Read ↗

Understanding the functions of BRCA1 in the DNA-damage response.Semantic proximity Read ↗

The functions of breast cancer susceptibility gene 1 (BRCA1) product and its associated proteins.Semantic proximity Read ↗

Roles of BRCA1 and its interacting proteins.Semantic proximity Read ↗

The role of BRCA1 in DNA double-strand repair: past and present.Semantic proximity Read ↗

The relationship between the roles of BRCA genes in DNA repair and cancer predisposition.Semantic proximity Read ↗

BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution.Semantic proximity Read ↗

In brief: BRCA1 and BRCA2.Semantic proximity Read ↗

[Advance in researches on BRCA1].Semantic proximity Read ↗

The DNA double-strand break response pathway: becoming more BRCAish than ever.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.