Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Histone chaperone ASF1 acts with RIF1 to promote DNA end joining in BRCA1-deficient cells

25 Apr 2022

Abstract excerpt

Replication timing regulatory factor 1 (RIF1) acts downstream of p53-binding protein 53BP1 to inhibit the resection of DNA broken ends, which plays critical roles in determining the DNA double-strand break repair pathway choice between nonhomologous end joining and homologous recombination (HR). However, the mechanism by which this choice is made is not yet clear. In this study, we identified that histone...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to DNA Repair Mechanisms
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35472331
DOI: 10.1016/j.jbc.2022.101979

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Histone chaperone ASF1 acts with RIF1 to promote DNA end joining in BRCA1-deficient cellsPMID 35472331Read ↗

RIF1-ASF1-mediated high-order chromatin structure safeguards genome integritySemantic proximity Read ↗

RIF1: A novel regulatory factor for DNA replication and DNA damage response signalingSemantic proximity Read ↗

A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choice.Semantic proximity Read ↗

ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand BreaksSemantic proximity Read ↗

Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaksSemantic proximity Read ↗

Rif1: A Conserved Regulator of DNA Replication and Repair Hijacked by Telomeres in YeastsSemantic proximity Read ↗

Histone ADP-ribosylation promotes resistance to PARP inhibitors by facilitating PARP1 release from DNA lesionsSemantic proximity Read ↗

DNA double-strand break repair: a tale of pathway choicesSemantic proximity Read ↗

Remodeling and spacing factor 1 (RSF1) deposits centromere proteins at DNA double-strand breaks to promote non-homologous end-joiningSemantic proximity Read ↗

E2F1 facilitates DNA break repair by localizing to break sites and enhancing the expression of homologous recombination factorsSemantic proximity Read ↗

SMARCAL1: a DNA repair protein recruited to double-strand breaks at stalled replication forks to promote genome stability through a homologous recombination pathwaySemantic proximity Read ↗

The role of BRCA1 in homologous recombination repair in response to replication stress: significance in tumorigenesis and cancer therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.