Article
A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choice.
Nature communications - 5 Jan 2016
Zhang Haoxing, Liu Hailong, Chen Yali, Yang Xu, Wang Panfei, Liu Tongzheng, Deng Min, Qin Bo, Correia Cristina, Lee Seungbaek, Kim Jungjin, Sparks Melanie, Nair Asha A, Evans Debra L, Kalari Krishna R, Zhang Pumin, Wang Liewei, You Zhongsheng, Kaufmann Scott H, Lou Zhenkun, Pei Huadong
Abstract excerpt
BRCA1 is an important mediator of the DNA damage response, which promotes homologous recombination (HR) and antagonizes 53BP1-dependent non-homologous end joining in S/G2 phase. But how this is achieved remains unclear. Here, we report that the E3 ubiquitin ligase UHRF1 (Ubiquitin-like, with PHD and RING finger domains 1) directly participates in the interplay between BRCA1 and 53BP1. Mechanistically, UHRF1 is...
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