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Article

RIF1-ASF1-mediated high-order chromatin structure safeguards genome integrity

17 Feb 2022

Abstract excerpt

The 53BP1-RIF1 pathway antagonizes resection of DNA broken ends and confers PARP inhibitor sensitivity on BRCA1-mutated tumors. However, it is unclear how this pathway suppresses initiation of resection. Here, we identify ASF1 as a partner of RIF1 via an interacting manner similar to its interactions with histone chaperones CAF-1 and HIRA. ASF1 is recruited to distal chromatin flanking DNA breaks by 53BP1-RIF1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35177609
DOI: 10.1038/s41467-022-28588-y

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