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Article

Overview of Roles of Novel Components in the Regulation of DNA Damage Repair in BRCA1-deficient Cancers: An Update

2025-02-03

Abstract excerpt

Cancers that are arising from germline mutations of the breast cancer associated gene 1 (BRCA1), which is a crucial player of homologous recombination (HR) DNA repair, are vulnerable to DNA damaging agents such as platinum and PARP inhibitors (PAR-Pi). Increasing evidence suggests that BRCA1 is an essential driver of all phases of the cell cycle, thereby maintaining orderly steps during cell cycle progression. Spe...

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Literature Corpus work
fac8b9b9-1ef0-5280-abf1-bf1091d20548
DOI
10.20944/preprints202502.0062.v1
Open publication

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Overview of Roles of Novel Components in the Regulation of DNA Damage Repair in BRCA1-deficient Cancers: An UpdateDOI 10.20944/preprints202502.0062.v1
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