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RAP1/TERF2IP—A Multifunctional Player in Cancer Development

27 Nov 2021

Abstract excerpt

Mammalian RAP1 (TERF2IP), the most conserved shelterin component, plays a pleiotropic role in the regulation of a variety of cellular processes, including cell metabolism, DNA damage response, and NF-κB signaling, beyond its canonical telomeric role. Moreover, it has been demonstrated to be involved in oncogenesis, progression, and chemoresistance in human cancers. Several mutations and different expression...

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PMID: 34885080
DOI: 10.3390/cancers13235970

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