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H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ

18 Apr 2022

Abstract excerpt

The 53BP1-RIF1-shieldin pathway maintains genome stability by suppressing nucleolytic degradation of DNA ends at double-strand breaks (DSBs). Although RIF1 interacts with damaged chromatin via phospho-53BP1 and facilitates recruitment of the shieldin complex to DSBs, it is unclear whether other regulatory cues contribute to this response. Here, we implicate methylation of histone H3 at lysine 4 by SETD1A-BOD1L in...

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PMID: 35439434
DOI: 10.1016/j.molcel.2022.03.030

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