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Article

Single mutations in tau modulate the populations of fibril conformers through seed selection.

Angewandte Chemie (International ed. in English) - 3 Feb 2014

Meyer Virginia, Dinkel Paul D, Luo Yin, Yu Xiang, Wei Guanghong, Zheng Jie, Eaton Gareth R, Ma Buyong, Nussinov Ruth, Eaton Sandra S, Margittai Martin

Abstract excerpt

Seeded conversion of tau monomers into fibrils is a central step in the progression of tau pathology in Alzheimer's disease and other neurodegenerative disorders. Self-assembly is mediated by the microtubule binding repeats in tau. There are either three or four repeats present depending on the protein isoform. Here, double electron-electron resonance spectroscopy was used to investigate the conformational...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24453187
DOI: 10.1002/anie.201308473
PMCID: PMC4083751

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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