Article
Diverse, evolving conformer populations drive distinct phenotypes in frontotemporal lobar degeneration caused by the same MAPT-P301L mutation.
Acta neuropathologica - 1 Jun 2020
Daude Nathalie, Kim Chae, Kang Sang-Gyun, Eskandari-Sedighi Ghazaleh, Haldiman Tracy, Yang Jing, Fleck Shelaine C, Gomez-Cardona Erik, Han Zhuang Zhuang, Borrego-Ecija Sergi, Wohlgemuth Serene, Julien Olivier, Wille Holger, Molina-Porcel Laura, Gelpi Ellen, Safar Jiri G, Westaway David
Abstract excerpt
Tau protein accumulation is a common denominator of major dementias, but this process is inhomogeneous, even when triggered by the same germline mutation. We considered stochastic misfolding of human tau conformers followed by templated conversion of native monomers as an underlying mechanism and derived sensitive conformational assays to test this concept. Assessments of brains from aged TgTauP301L transgenic...
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