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Article

Distinct populations of highly potent TAU seed conformers in rapidly progressing Alzheimer’s disease

5 Jan 2022

Abstract excerpt

Although genetic factors play a main role in determining the risk of developing Alzheimer’s disease (AD), they do not explain extensive spectrum of clinicopathological phenotypes. Deposits of aggregated TAU proteins are one of the main predictors of cognitive decline in AD. We investigated the hypothesis that variabilities in AD progression could be due to diverse structural assemblies (strains) of TAU protein....

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PMID: 34985969
DOI: 10.1126/scitranslmed.abg0253

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