Article

Tau P301L mutation promotes core 4R tauopathy fibril fold through near-surface water structuring and conformational rearrangement

2023-11-28

Abstract excerpt

Tau forms toxic fibrillar aggregates in a family of neurodegenerative diseases known as tauopathies. The faithful replication of tauopathy-specific fibril structures is a critical gap for developing diagnostic and therapeutic tools. This study debuts a strategy of identifying a critical segment of tau that forms a folding motif that is characteristic of a family of tauopathies and isolating it as a standalone pept...

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Identifiers and source

Literature Corpus work: 0806e0af-f320-56be-95b1-76e005b17fca
DOI: 10.1101/2023.11.28.568818

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