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Article

Revealing the conformational landscape of tau P → L mutants in R23 tau macromolecule: A pathway to targeted therapeutic design.

International journal of biological macromolecules - 1 Feb 2026

Li Hao, Kim Hyundong, Kim Myounwoo, Lee Jin Yong

Abstract excerpt

Misfolding of the microtubule-associated protein tau is central to the pathology of several neurodegenerative disorders, including Alzheimer's disease, Pick's disease, and progressive supranuclear palsy. Although proline-to-leucine (P → L) substitutions in tau are known to accelerate aggregation, the molecular mechanisms underlying this effect-and potential strategies to counter it-remain incompletely understood....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41519344
DOI: 10.1016/j.ijbiomac.2025.150033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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