Article
Construction of a chimeric hepatitis C virus replicon based on a strain isolated from a chronic hepatitis C patient.
Virologica Sinica - 1 Feb 2014
Cao Huang, Zhu Wandi, Han Qingxia, Pei Rongjuan, Chen Xinwen
Abstract excerpt
Subgenomic replicons of hepatitis C virus (HCV) have been widely used for studying HCV replication. Here, we report a new subgenomic replicon based on a strain isolated from a chronically infected patient. The coding sequence of HCV was recovered from a Chinese chronic hepatitis C patient displaying high serum HCV copy numbers. A consensus sequence designated as CCH strain was constructed based on the sequences...
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