Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The NS3 helicase and NS5B-to-3'X regions are important for efficient hepatitis C virus strain JFH-1 replication in Huh7 cells.

Journal of virology - 1 Aug 2007

Murayama Asako, Date Tomoko, Morikawa Kenichi, Akazawa Daisuke, Miyamoto Michiko, Kaga Minako, Ishii Koji, Suzuki Tetsuro, Kato Takanobu, Mizokami Masashi, Wakita Takaji

Abstract excerpt

The JFH-1 strain of hepatitis C virus (HCV) is a genotype 2a strain that can replicate autonomously in Huh7 cells. The J6 strain is also a genotype 2a strain, but its full genomic RNA does not replicate in Huh7 cells. However, chimeric J6/JFH-1 RNA that has J6 structural-protein-coding regions an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to Hepacivirus
Share to Replicon

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to RNA Helicases

Share to RNA, Viral

Share to Viral Nonstructural Proteins

Share to Viral Proteins

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 17522229
DOI: 10.1128/JVI.02088-06
PMCID: PMC1951293

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17522229-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The NS3 helicase and NS5B-to-3'X regions are important for efficient hepatitis C virus strain JFH-1 replication in Huh7 cells.PMID 17522229Read ↗

RNA Polymerase Activity and Specific RNA Structure Are Required for Efficient HCV Replication in Cultured CellsSemantic proximity Read ↗

Amino Acid Mutations in the NS4A Region of Hepatitis C Virus Contribute to Viral Replication and Infectious Virus Production.Semantic proximity Read ↗

Production of infectious chimeric hepatitis C virus genotype 2b harboring minimal regions of JFH-1.Semantic proximity Read ↗

Production of infectious hepatitis C virus of various genotypes in cell cultures.Semantic proximity Read ↗

A comprehensive structure-function comparison of hepatitis C virus strain JFH1 and J6 polymerases reveals a key residue stimulating replication in cell culture across genotypes.Semantic proximity Read ↗

Compensatory mutations in E1, p7, NS2, and NS3 enhance yields of cell culture-infectious intergenotypic chimeric hepatitis C virus.Semantic proximity Read ↗

Isolation of JFH-1 strain and development of an HCV infection system.Semantic proximity Read ↗

Genotype 2a hepatitis C virus subgenomic replicon can replicate in HepG2 and IMY-N9 cells.Semantic proximity Read ↗

Full-length infectious HCV chimeras.Semantic proximity Read ↗

Hepatitis C virus p7 and NS2 proteins are essential for production of infectious virus.Semantic proximity Read ↗

Efficient infectious cell culture systems of the hepatitis C virus (HCV) prototype strains HCV-1 and H77.Semantic proximity Read ↗

Novel cell culture-adapted genotype 2a hepatitis C virus infectious clone.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.