Article
The hepatitis C virus replicon system and its application to molecular studies.
Current opinion in drug discovery & development - 1 Sept 2001
Pietschmann T, Bartenschlager R
Abstract excerpt
The hepatitis C virus (HCV) was identified as the major causative agent of post-transfusion and sporadic non-A, non-B hepatitis. Approximately 170 million individuals worldwide are afflicted with this infection that in most cases becomes persistent. The clinical outcomes are varied, ranging from an apparently healthy carrier state to liver cirrhosis and even hepatocellular carcinoma. Thus far, no vaccine is...
Topics
- Animals
- Cells, Cultured
- DNA Replication
- Hepacivirus
- Humans
- Mutation
- Replicon
- Virus Replication