Article
Novel cell culture-adapted genotype 2a hepatitis C virus infectious clone.
Journal of virology - 1 Oct 2012
Date Tomoko, Kato Takanobu, Kato Junko, Takahashi Hitoshi, Morikawa Kenichi, Akazawa Daisuke, Murayama Asako, Tanaka-Kaneko Keiko, Sata Tetsutaro, Tanaka Yasuhito, Mizokami Masashi, Wakita Takaji
Abstract excerpt
Although the recently developed infectious hepatitis C virus system that uses the JFH-1 clone enables the study of whole HCV viral life cycles, limited particular HCV strains have been available with the system. In this study, we isolated another genotype 2a HCV cDNA, the JFH-2 strain, from a patient with fulminant hepatitis. JFH-2 subgenomic replicons were constructed. HuH-7 cells transfected with in vitro...
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