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Article

Cutting the gordian knot-development and biological relevance of hepatitis C virus cell culture systems.

Advances in virus research - 1 Jan 2008

Gottwein Judith M, Bukh Jens

Abstract excerpt

Worldwide approximately 180 million people are chronically infected with hepatitis C virus (HCV). HCV isolates exhibit extensive genetic heterogeneity and have been grouped in six genotypes and various subtypes. Additionally, several naturally occurring intergenotypic recombinants have been described. Research on the viral life cycle, efficient therapeutics, and a vaccine has been hampered by the absence of...

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PMID: 18585527
DOI: 10.1016/S0065-3527(08)00002-X

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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