Article
Comparison between subgenomic replicons of hepatitis C virus genotypes 2a (JFH-1) and 1b (Con1 NK5.1).
Intervirology - 1 Jan 2006
Miyamoto Michiko, Kato Takanobu, Date Tomoko, Mizokami Masashi, Wakita Takaji
Abstract excerpt
Although replicon systems for hepatitis C virus (HCV) recently developed have enabled the replication of HCV in cultured cells, limited genotypes are available for them. We have isolated HCV cDNA of genotype 2a (JFH-1 strain) from serum of a patient with fulminant hepatitis. A subgenomic replicon of JFH-1 was constructed and compared with the HCV replicon of genotype 1b (Con1 NK5.1) which possessed adaptive...
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