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Efficient replication of a full-length hepatitis C virus genome, strain O, in cell culture, and development of a luciferase reporter system.

Biochemical and biophysical research communications - 22 Apr 2005

Ikeda Masanori, Abe Ken-Ichi, Dansako Hiromichi, Nakamura Takashi, Naka Kazuhito, Kato Nobuyuki

Abstract excerpt

Recently we reported a subgenomic hepatitis C virus (HCV) replicon derived from HCV (HCV-O strain) infected in non-neoplastic human hepatocyte PH5CH8. In this study, we developed a genome-length dicistronic HCV RNA from HCV-O. A cured HuH-7 cell line (sOc) was obtained from a cloned subgenomic replicon cell line (sO) by interferon (IFN) treatment and used for transfection with genome-length HCV RNA. One cloned...

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Identifiers

PMID: 15766575
DOI: 10.1016/j.bbrc.2005.02.138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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