Article
Association of TOMM40 polymorphisms with late-onset Alzheimer's disease in a Northern Han Chinese population.
Neuromolecular medicine - 1 Jun 2013
Ma Xiao-Ying, Yu Jin-Tai, Wang Wei, Wang Hui-Fu, Liu Qiu-Yan, Zhang Wei, Tan Lan
Abstract excerpt
Mitochondrial dysfunction is an early defect in the pathogenesis of late-onset Alzheimer's disease (LOAD). One interesting candidate gene for mitochondrial dysfunction in LOAD is the translocase of outer mitochondrial membrane 40 homolog (TOMM40) gene. Several single nucleotide polymorphisms (SNPs) within TOMM40 have been shown to affect susceptibility to LOAD in Caucasians, while there are no studies on the...
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