Article
Variability in the CIITA gene interacts with HLA in multiple sclerosis.
Genes and immunity - 1 Jan 2000
Gyllenberg A, Piehl F, Alfredsson L, Hillert J, Bomfim I L, Padyukov L, Orho-Melander M, Lindholm E, Landin-Olsson M, Lernmark Å, Olsson T, Kockum I
Abstract excerpt
The human leukocyte antigen (HLA) is the main genetic determinant of multiple sclerosis (MS) risk. Within the HLA, the class II HLA-DRB1*15:01 allele exerts a disease-promoting effect, whereas the class I HLA-A*02 allele is protective. The CIITA gene is crucial for expression of class II HLA molecules and has previously been found to associate with several autoimmune diseases, including MS and type 1 diabetes. We...
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