Article
CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis.
Human molecular genetics - 1 Jun 2010
Bronson Paola G, Caillier Stacy, Ramsay Patricia P, McCauley Jacob L, Zuvich Rebecca L, De Jager Philip L, Rioux John D, Ivinson Adrian J, Compston Alastair, Hafler David A, Sawcer Stephen J, Pericak-Vance Margaret A, Haines Jonathan L, Hauser Stephen L, Oksenberg Jorge R, Barcellos Lisa F
Abstract excerpt
The MHC class II transactivator gene (CIITA) is an important transcription factor regulating gene required for HLA class II MHC-restricted antigen presentation. Association with HLA class II variation, particularly HLA-DRB1*1501, has been well-established for multiple sclerosis (MS). In addition, the -168A/G CIITA promoter variant (rs3087456) has been reported to be associated with MS. Thus, a multi-stage...
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