Article
Phosphatidylinositol 4,5-biphosphate (PIP2) modulates interaction of syntaxin-1A with sulfonylurea receptor 1 to regulate pancreatic β-cell ATP-sensitive potassium channels.
The Journal of biological chemistry - 28 Feb 2014
Liang Tao, Xie Li, Chao Christin, Kang Youhou, Lin Xianguang, Qin Tairan, Xie Huanli, Feng Zhong-Ping, Gaisano Herbert Y
Abstract excerpt
In β-cells, syntaxin (Syn)-1A interacts with SUR1 to inhibit ATP-sensitive potassium channels (KATP channels). PIP2 binds the Kir6.2 subunit to open KATP channels. PIP2 also modifies Syn-1A clustering in plasma membrane (PM) that may alter Syn-1A actions on PM proteins like SUR1. Here, we assesse...
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