Article
Mutations of the Ca2+-sensing stromal interaction molecule STIM1 regulate Ca2+ influx by altered oligomerization of STIM1 and by destabilization of the Ca2+ channel Orai1.
The Journal of biological chemistry - 18 Jan 2013
Kilch Tatiana, Alansary Dalia, Peglow Martin, Dörr Kathrin, Rychkov Grigori, Rieger Heiko, Peinelt Christine, Niemeyer Barbara A
Abstract excerpt
A drop of endoplasmic reticulum Ca(2+) concentration triggers its Ca(2+) ssensor protein stromal interaction molecule 1 (STIM1) to oligomerize and accumulate within endoplasmic reticulum-plasma membrane junctions where it activates Orai1 channels, providing store-operated Ca(2+) entry. To elucidate the functional significance of N-glycosylation sites of STIM1, we created different mutations of asparagine-131 and...
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