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Article

Kir2.1 Interactome Mapping Uncovers PKP4 as a Modulator of the Kir2.1-Regulated Inward Rectifier Potassium Currents.

Molecular & cellular proteomics : MCP - 1 Sept 2020

Park Sung-Soo, Ponce-Balbuena Daniela, Kuick Rork, Guerrero-Serna Guadalupe, Yoon Justin, Mellacheruvu Dattatreya, Conlon Kevin P, Basrur Venkatesha, Nesvizhskii Alexey I, Jalife José, Rual Jean-François

Abstract excerpt

Kir2.1, a strong inward rectifier potassium channel encoded by the KCNJ2 gene, is a key regulator of the resting membrane potential of the cardiomyocyte and plays an important role in controlling ventricular excitation and action potential duration in the human heart. Mutations in KCNJ2 result in inheritable cardiac diseases in humans, e.g. the type-1 Andersen-Tawil syndrome (ATS1). Understanding the molecular...

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Source

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Identifiers

PMID: 32541000
DOI: 10.1074/mcp.RA120.002071
PMCID: PMC8143648

Genes

KCNJ2
PKP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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