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Article

Syntaxin 4 and Synip (syntaxin 4 interacting protein) regulate insulin secretion in the pancreatic beta HC-9 cell.

The Journal of biological chemistry - 19 Sept 2003

Saito Tsugumichi, Okada Shuichi, Yamada Eijiro, Ohshima Kihachi, Shimizu Hiroyuki, Shimomura Kenju, Sato Minoru, Pessin Jeffrey E, Mori Masatomo

Abstract excerpt

Although syntaxin 1 is generally thought to function as the primary target-N-ethylmaleimide-sensitive factor attachment protein receptor required for pancreatic beta cell insulin secretion, we have observed that overexpression of a dominant-interfering syntaxin 4 mutant (syntaxin 4/DeltaTM) attenuated glucose-stimulated insulin secretion in betaHC-9 cells. Furthermore, these cells express the selective syntaxin...

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Identifiers

PMID: 12855681
DOI: 10.1074/jbc.M305114200

Genes

VAMP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Syntaxin 4 and Synip (syntaxin 4 interacting protein) regulate insulin secretion in the pancreatic beta HC-9 cell.PMID 12855681Read ↗

Synip: a novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytes.Semantic proximity Read ↗

Synip phosphorylation is required for insulin-stimulated Glut4 translocation.Semantic proximity Read ↗

H3 domain of syntaxin 1A inhibits KATP channels by its actions on the sulfonylurea receptor 1 nucleotide-binding folds-1 and -2.Semantic proximity Read ↗

Phosphatidylinositol 4,5-biphosphate (PIP2) modulates interaction of syntaxin-1A with sulfonylurea receptor 1 to regulate pancreatic β-cell ATP-sensitive potassium channels.Semantic proximity Read ↗

Munc18c depletion selectively impairs the sustained phase of insulin release.Semantic proximity Read ↗

WNK1 is a novel regulator of Munc18c-syntaxin 4 complex formation in soluble NSF attachment protein receptor (SNARE)-mediated vesicle exocytosis.Semantic proximity Read ↗

Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions.Semantic proximity Read ↗

Genetic and electrophysiological studies of Drosophila syntaxin-1A demonstrate its role in nonneuronal secretion and neurotransmission.Semantic proximity Read ↗

Syntaxin-6 SNARE involvement in secretory and endocytic pathways of cultured pancreatic beta-cells.Semantic proximity Read ↗

Molecular determinants of syntaxin 1 modulation of N-type calcium channels.Semantic proximity Read ↗

Targeted mutations in the syntaxin H3 domain specifically disrupt SNARE complex function in synaptic transmission.Semantic proximity Read ↗

The non-neuronal syntaxin SYN-1 regulates defecation behavior and neural activity in C. elegans through interaction with the Munc13-like protein AEX-1.Semantic proximity Read ↗

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