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Article

Sulfonylurea receptor 1 mutations that cause opposite insulin secretion defects with chemical chaperone exposure.

The Journal of biological chemistry - 20 Mar 2009

Pratt Emily B, Yan Fei-Fei, Gay Joel W, Stanley Charles A, Shyng Show-Ling

Abstract excerpt

The beta-cell ATP-sensitive potassium (K(ATP)) channel composed of sulfonylurea receptor SUR1 and potassium channel Kir6.2 serves a key role in insulin secretion regulation by linking glucose metabolism to cell excitability. Mutations in SUR1 or Kir6.2 that decrease channel function are typically associated with congenital hyperinsulinism, whereas those that increase channel function are associated with neonatal...

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Source

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Identifiers

PMID: 19151370
DOI: 10.1074/jbc.M807012200
PMCID: PMC2658088

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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