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Article

Effects of Serine 129 Phosphorylation on α-Synuclein Aggregation, Membrane Association, and Internalization.

The Journal of biological chemistry - 26 Feb 2016

Samuel Filsy, Flavin William P, Iqbal Sobia, Pacelli Consiglia, Sri Renganathan Sri Dushyaanthan, Trudeau Louis-Eric, Campbell Edward M, Fraser Paul E, Tandon Anurag

Abstract excerpt

Although trace levels of phosphorylated α-synuclein (α-syn) are detectable in normal brains, nearly all α-syn accumulated within Lewy bodies in Parkinson disease brains is phosphorylated on serine 129 (Ser-129). The role of the phosphoserine residue and its effects on α-syn structure, function, and intracellular accumulation are poorly understood. Here, co-expression of α-syn and polo-like kinase 2 (PLK2), a...

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Identifiers

PMID: 26719332
DOI: 10.1074/jbc.M115.705095
PMCID: PMC4813466

Genes

PLK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Effects of Serine 129 Phosphorylation on α-Synuclein Aggregation, Membrane Association, and Internalization.PMID 26719332Read ↗

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