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Article

H3 domain of syntaxin 1A inhibits KATP channels by its actions on the sulfonylurea receptor 1 nucleotide-binding folds-1 and -2.

The Journal of biological chemistry - 17 Dec 2004

Cui Ningren, Kang Youhou, He Yan, Leung Yuk-Man, Xie Huanli, Pasyk Ewa A, Gao Xiaodong, Sheu Laura, Hansen John B, Wahl Philip, Tsushima Robert G, Gaisano Herbert Y

Abstract excerpt

The ATP-sensitive potassium (K(ATP)) channel in pancreatic islet beta cells consists of four pore-forming (Kir6.2) subunits and four regulatory sulfonylurea receptor (SUR1) subunits. In beta cells, the K(ATP) channel links intracellular metabolism to the dynamic regulation of the cell membrane potential that triggers insulin secretion. Syntaxin 1A (Syn-1A) is a SNARE protein that not only plays a direct role in...

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Identifiers

PMID: 15485808
DOI: 10.1074/jbc.M410171200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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H3 domain of syntaxin 1A inhibits KATP channels by its actions on the sulfonylurea receptor 1 nucleotide-binding folds-1 and -2.PMID 15485808Read ↗

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