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Article

A role of the sulfonylurea receptor 1 in endocytic trafficking of ATP-sensitive potassium channels.

Traffic (Copenhagen, Denmark) - 1 Sept 2011

Bruederle Cathrin E, Gay Joel, Shyng Show-Ling

Abstract excerpt

The ATP-sensitive potassium (K(ATP) ) channel consisting of sulfonylurea receptor 1 (SUR1) and inward-rectifier potassium channel 6.2 (Kir6.2) has a well-established role in insulin secretion. Mutations in either subunit can lead to disease due to aberrant channel gating, altered channel density at the cell surface or a combination of both. Endocytic trafficking of channels at the plasma membrane is one way to...

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Identifiers

PMID: 21649805
DOI: 10.1111/j.1600-0854.2011.01227.x
PMCID: PMC3155645

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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A role of the sulfonylurea receptor 1 in endocytic trafficking of ATP-sensitive potassium channels.PMID 21649805Read ↗

Kir6.2 mutations causing neonatal diabetes prevent endocytosis of ATP-sensitive potassium channels.Semantic proximity Read ↗

Identification of a familial hyperinsulinism-causing mutation in the sulfonylurea receptor 1 that prevents normal trafficking and function of KATP channels.Semantic proximity Read ↗

Trafficking of ATP-sensitive potassium channels in health and disease.Semantic proximity Read ↗

Defective trafficking and function of KATP channels caused by a sulfonylurea receptor 1 mutation associated with persistent hyperinsulinemic hypoglycemia of infancy.Semantic proximity Read ↗

Sulfonylurea receptor 1 mutations that cause opposite insulin secretion defects with chemical chaperone exposure.Semantic proximity Read ↗

Pharmacological Correction of Trafficking Defects in ATP-sensitive Potassium Channels Caused by Sulfonylurea Receptor 1 Mutations.Semantic proximity Read ↗

Sulfonylureas correct trafficking defects of ATP-sensitive potassium channels caused by mutations in the sulfonylurea receptor.Semantic proximity Read ↗

Assembly, maturation, and turnover of K(ATP) channel subunits.Semantic proximity Read ↗

Modulation of the trafficking efficiency and functional properties of ATP-sensitive potassium channels through a single amino acid in the sulfonylurea receptor.Semantic proximity Read ↗

Sulfonylureas correct trafficking defects of disease-causing ATP-sensitive potassium channels by binding to the channel complex.Semantic proximity Read ↗

ATP-sensitive potassium channels: a model of heteromultimeric potassium channel/receptor assemblies.Semantic proximity Read ↗

N-terminal transmembrane domain of SUR1 controls gating of Kir6.2 by modulating channel sensitivity to PIP2.Semantic proximity Read ↗

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