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Article

The Dual Function of the Polybasic Juxtamembrane Region of Syntaxin 1A in Clamping Spontaneous Release and Stimulating Ca2+-Triggered Release in Neuroendocrine Cells.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 3 Jan 2018

Singer-Lahat Dafna, Barak-Broner Noa, Sheinin Anton, Greitzer-Antes Dafna, Michaelevski Izhak, Lotan Ilana

Abstract excerpt

The exact function of the polybasic juxtamembrane region (5RK) of the plasma membrane neuronal SNARE, syntaxin 1A (Syx), in vesicle exocytosis, although widely studied, is currently not clear. Here, we addressed the role of 5RK in Ca2+-triggered release, using our Syx-based intramolecular fluorescence resonance energy transfer (FRET) probe, which previously allowed us to resolve a depolarization-induced...

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Identifiers

PMID: 29133430
DOI: 10.1523/JNEUROSCI.1541-17.2017
PMCID: PMC6705805

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Dual Function of the Polybasic Juxtamembrane Region of Syntaxin 1A in Clamping Spontaneous Release and Stimulating Ca2+-Triggered Release in Neuroendocrine Cells.PMID 29133430Read ↗

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