Article
Synip: a novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytes.
Molecular cell - 1 Jun 1999
Min J, Okada S, Kanzaki M, Elmendorf J S, Coker K J, Ceresa B P, Syu L J, Noda Y, Saltiel A R, Pessin J E
Abstract excerpt
Insulin-stimulated glucose transport and GLUT4 translocation require regulated interactions between the v-SNARE, VAMP2, and the t-SNARE, syntaxin 4. We have isolated a novel syntaxin 4-binding protein, Synip, which specifically interacts with syntaxin 4. Insulin induces a dissociation of the Synip:syntaxin 4 complex due to an apparent decrease in the binding affinity of Synip for syntaxin 4. In contrast, the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.