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Article

Daptomycin production enhancement by ARTP mutagenesis and fermentation optimization in Streptomyces roseosporus.

Journal of applied microbiology - 4 Oct 2023

Zhu Chen-Yang, Zhao Xin-Yi, Lyu Zhong-Yuan, Gao Wen-Li, Zhao Qing-Wei, Chen Xin-Ai, Li Yong-Quan

Abstract excerpt

AIMS: We evaluated whether the randomness of mutation breeding can be regulated through a double-reporter system. We hope that by establishing a new precursor feeding strategy, the production capacity of industrial microorganisms after pilot scale-up can be further improved. METHODS AND RESULTS: In this study, the industrial strain Streptomyces roseosporus L2796 was used as the starter strain for daptomycin...

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PMID: 37873659
DOI: 10.1093/jambio/lxad230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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